What the older diet-and-exercise trials found in the hip
The evidence base is one secondary analysis, several small studies and a large amount of extrapolation from bariatric surgery.
February 2024
Everything filed in February 2024, the month of Volume 1, Number 2. The issue itself — cover, editor’s letter and table of contents — is here.
The relabeller trading as Vantris Bio closes after 10 years
A proper account of an operation that existed, and of what closing it cost.
Ireland declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
FGP declines, for the 3rd time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The label says four weeks. The clinic says whatever holds.
What the regulatory dossiers actually contain on dose selection is remarkably thin, and worth knowing before treating the ladder as settled science.
Six words a verification badge would need to mean anything
A badge asserts that something was tested. It does not assert what, when, on whose sample, by what method, or whether the lot on sale is the lot that was tested.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
South Korea caps tirzepatide prescribing to 21 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at JEEP in February, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the new Ireland guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Why the bone question is harder than the muscle question
The evidence base is one secondary analysis, several small studies and a large amount of extrapolation from bariatric surgery.
What a 1 mL syringe does that a 0.3 mL syringe does not
We work through the arithmetic in full, because it is short, and because the errors it prevents are order-of-magnitude errors.
Escalating past the approved maximum, examined honestly
The ceiling in this class is anatomical: the same receptor populations that suppress appetite provoke nausea, and they saturate together.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Sweden declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to France after 3 consecutive customs detentions
The route did not close because of a rule about peptides.
How a claim degrades between the bench and the listing
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
The online reseller trading as Adamant Research Supply closes after 20 years
A proper account of an operation that existed, and of what closing it cost.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
STEP 1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A shortage listing ends. 11 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The submitted sample: the weakest link in the whole system
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
The named comparison we promised two years ago
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
Randomised withdrawal is the cleanest design in this field and the least discussed
The regain trajectories, arm by arm, with the estimands named.
The quiet end of the consolidator trading as Meridian Freight Partners
A proper account of an operation that existed, and of what closing it cost.
South Korea health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
BCH declines, for the 7th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 30-day notice: how a compounding wind-down works in Italy
The document is four pages. Three of them are about dates.
The batch number is the only thing connecting the page to the vial
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Reading HbA1c in the presence of anaemia
The alternatives with shorter windows, what they measure, and why they are rarely ordered.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
QSC declines, for the 8th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a WWB liraglutide lot at 98.2%, against 96.5% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
A shortage listing ends. 8 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Two sessions a week, and the evidence behind the prescription
Mass and function are different endpoints and training affects them differently. Most coverage treats them as one.
What the anaesthetists said, and then said again
What endoscopic and ultrasound studies found about residual gastric content, and what the aspiration data does and does not support.
The trade has decided the ceiling is arbitrary. The trials disagree.
The ceiling in this class is anatomical: the same receptor populations that suppress appetite provoke nausea, and they saturate together.
A shortage listing ends. 11 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What changed at SWB in February, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.