Accuracy, precision and the tolerance nobody states
Parts per million sound impressive until they are converted into daltons at the molecular weight of the thing being measured.
The archive
Everything the Journal has published, in reverse chronological order — features, department pieces and newsroom dispatches together. The archive is complete: nothing is unpublished, and corrected pieces remain in place with their corrections attached.
STEP 2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
What the new Argentina guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The consolidator trading as Meridian Freight Partners closes after 9 years
A proper account of an operation that existed, and of what closing it cost.
In-use periods, and the ones nobody can give you
The air shot before a pen injection removes air from the cartridge and confirms flow. Skipping it can mean a materially reduced dose, and it is skipped constantly.
The named comparison we promised two years ago
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
What changed at SWB in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 17 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Poland declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-4 was built to answer the stopping question, and it did
The regain trajectories, arm by arm, with the estimands named.
Set the threshold at a tenth of a per cent and the small impurities vanish
We work through a single chromatogram twice, under two integration conventions, and show where the difference comes from.
What changed at SSA in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the new Japan guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Halvard & Pike Apothecary of Portland, Maine closes after 21 years
A proper account of an operation that existed, and of what closing it cost.
Poland caps semaglutide prescribing to 22 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Hydrolysis, isomerisation, and the arithmetic of a broken bond
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
What the labels permit, what clinicians do, and the size of the gap between them.
SGN declines, for the 21st time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 7 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Sweden caps liraglutide prescribing to 24 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Same material, different gradients, different answers
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
Maximum tolerated is not maximum approved
Weight reduction in the long programmes flattens at roughly sixty to seventy-two weeks. The timing is consistent, predictable and almost never mentioned in advance.
What a month without the drug does to tolerability
Concentrations fall by half a week, so a month away leaves a small fraction of steady state. Resuming at the previous dose presents the receptor with a step it has not seen…
The 9-day notice: how a compounding wind-down works in the United Arab Emirates
The document is four pages. Three of them are about dates.
Inspectors cite the consolidator trading as Meridian Freight Partners over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Independent analysis puts a TFC tirzepatide lot at 98.3%, against 95.4% on the certificate
The result is unremarkable. What the report omits is not.
Two sessions a week, and the evidence behind the prescription
One randomised trial has combined a GLP-1 receptor agonist with supervised exercise. Its result is the single most useful piece of evidence in this area.
Calder Vale Peptides of Skipton enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.