The out-of-range flag is a statistical convention with a printer attached
Almost every misreading of a laboratory panel is a misunderstanding of what a reference interval is and how much a result has to move before the movement means anything.
June 2024
Everything filed in June 2024, the month of Volume 1, Number 6. The issue itself — cover, editor’s letter and table of contents — is here.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What a 19% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
Why people actually stop, in the order they actually stop
The trials studied planned withdrawal. Almost nobody stops that way.
From vial to bench: what is recorded and what is assumed
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
Inspectors cite the relabeller trading as Vantris Bio over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Nigeria health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
TRIUMPH-1 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A shortage listing ends. 16 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Bone density during rapid weight loss: what is known, which is less than you would hope
Density is a proxy for strength and an imperfect one, particularly when soft-tissue thickness over the measurement site is changing.
Set the threshold at a tenth of a per cent and the small impurities vanish
We work through a single chromatogram twice, under two integration conventions, and show where the difference comes from.
From the floor in Shenzhen: 21 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Spain caps semaglutide prescribing to 20 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at TFC in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 29-day notice: how a compounding wind-down works in Australia
The document is four pages. Three of them are about dates.
The submitted sample: the weakest link in the whole system
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
What a low result means when intake has halved
What the trials measured, which in the case of micronutrients is very little.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
Ireland health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
Wuhan export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
The 11-day notice: how a compounding wind-down works in Canada
The document is four pages. Three of them are about dates.
What we asked twenty suppliers about stability data
A retest date says that material should be re-examined before use. An expiry date says it should not be used. The trade uses the second word for the first concept.
The mechanism behind the mechanism
What scintigraphy and breath-test studies established about emptying rate, and what they did not.
Why your endoscopist wants to know about your injection
This is the single interaction with ordinary medical care that patients most need to disclose, and it is the one most often not asked about.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
TRIUMPH-1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to Australia after 18 consecutive customs detentions
The route did not close because of a rule about peptides.
Pore size, particle size, and why peptides need the wide pores
A shallow gradient resolves impurities that a steep one runs into the parent peak. Both methods are legitimate; only one of them can see the small stuff.
What changed at MKM in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
The 27-day notice: how a compounding wind-down works in Switzerland
The document is four pages. Three of them are about dates.
The online reseller trading as Adamant Research Supply closes after 20 years
A proper account of an operation that existed, and of what closing it cost.
Escalating onto a rising curve
What the published pharmacokinetics permit, what the labels state, and where the two diverge.
Two-thirds back: the extension nobody expected to be the headline
The regain trajectories, arm by arm, with the estimands named.
STEP 5 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
India declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
A supplier suspends shipping to Australia after 24 consecutive customs detentions
The route did not close because of a rule about peptides.
A missed dose, modelled: what happens to liraglutide concentrations over the following fortnight
Half-life, accumulation ratio and time to steady state are three separate quantities, and confusing them produces most of the bad advice in circulation.