LEADER misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Archive — October 2024
Page 4 of 5 of this archive, newest first.
Spain declines to reimburse tirzepatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The quiet end of the consolidator trading as Meridian Freight Partners
A proper account of an operation that existed, and of what closing it cost.
What Medutest can tell you about a vial by weighing its water
Water is a reactant in hydrolysis, a plasticiser that mobilises the amorphous matrix, and a carrier for everything else. All three matter.
Reading a barrel in the wrong increments
Almost every case involves a change — a new vial, a new syringe size, a new supplier — carried forward with an old number.
Turkey caps semaglutide prescribing to 19 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at SGN in October, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 5 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
A tested vial is evidence about a vial
Every third-party report in this market describes a sample somebody chose to send. That choice is outside the laboratory’s control and outside its records.
The certificate is silent on contamination, and it never claimed otherwise
Every certificate circulating in this market answers a question about molecules. Almost none answers a question about organisms, pyrogens, or the integrity of the seal.
Saudi Arabia declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
FGP names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 16-day notice: how a compounding wind-down works in Ireland
The document is four pages. Three of them are about dates.
From the floor in Qingdao: 22 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Sending the same vial twice, under two names
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
D-amino acids are invisible to mass spectrometry, and that is the whole problem
Stereochemical inversion changes the molecule, changes its biology, and changes its mass by exactly nothing.
A few hundred participants carry the whole body-composition argument
What was pre-specified, what was exploratory, and what was calculated afterwards by people who did not run the trial.
The 9-day notice: how a compounding wind-down works in Saudi Arabia
The document is four pages. Three of them are about dates.
A supplier suspends shipping to Spain after 10 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
What we would need to randomise to answer this properly
The recommendation survives scrutiny. The reasoning offered for it frequently does not.
Japan pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
CPC names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
France declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Calder Vale Peptides of Skipton closes after 16 years
A proper account of an operation that existed, and of what closing it cost.
Escalating onto a rising curve
We work the arithmetic out in full, because it is arithmetic and it is short.
What the four services actually offer, test by test
Endotoxin is the more tractable of the two questions, and a kinetic chromogenic determination is neither slow nor exotic. It is simply not on the menu.
What the new Japan guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What changed at CPC in October, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Medutest result on a Xi'an semaglutide lot lands 3.3 points above the supplier’s stated figure
The supplier confirmed the determination and supplied the method behind its own figure inside a week.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
The dose that got you here and the dose that keeps you here
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
Hydration, protein and the two failures that compound each other
Almost nothing in the standard management repertoire has been tested in a randomised trial in this specific population. We say what is extrapolated and from where.
A supplier suspends shipping to Nigeria after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
From the floor in Changsha: 21 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Side effects, cost, supply, target: four reasons with four trajectories
Real-world persistence figures, with their definitions stated, because the definitions are doing most of the work.
Set the threshold at a tenth of a per cent and the small impurities vanish
Baseline placement under a tailing peak is a judgement call with a direct effect on the area. It is one of the few places where two competent analysts genuinely disagree.
The 13-day notice: how a compounding wind-down works in Argentina
The document is four pages. Three of them are about dates.