Five things a purity figure cannot tell you
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
February 2025
Everything filed in February 2025, the month of Volume 2, Number 2. The issue itself — cover, editor’s letter and table of contents — is here.
From the floor in Nantong: 3 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the new Australia guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
SURMOUNT-2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Independent analysis puts a WWB exenatide lot at 98.5%, against 96.6% on the certificate
The result is unremarkable. What the report omits is not.
What we would need to randomise to answer this properly
One randomised trial has combined a GLP-1 receptor agonist with supervised exercise. Its result is the single most useful piece of evidence in this area.
Why people actually stop, in the order they actually stop
Why the reason for stopping changes what happens afterwards.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A shortage listing ends. 22 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What a 15% rise in coupling-reagent prices does to a 20 mg vial
Follow the resin, not the catalogue.
Medutest result on a Nantong orforglipron lot lands 2.6 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
What the outcome trials measured in the kidney
Estimated glomerular filtration rate is a calculation with muscle mass in the denominator of its assumptions. In this population that matters.
Every fortnight, every third week, seasonally: an unstudied practice
An absence of evidence is not evidence of harm. It is also not a licence.
The change that weighs nothing at all
What would be needed to catch each of these, and what it would cost.
Qingdao export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Mexico health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
Homopeptide declines, for the 12th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a GGPeps retatrutide lot at 95.3%, against 92.8% on the certificate
The result is unremarkable. What the report omits is not.
What the trials counted as intolerance
The ceiling varies severalfold between people, and nothing measurable at baseline predicts where it sits.
Date of analysis, date of manufacture, and the gap between them
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
What changed at GGPeps in February, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
PeptideMeter result on a Wuxi cagrilintide lot lands 2.5 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.
From the floor in Wuxi: 14 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the new Italy guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The anatomy of the most reproduced page in this trade
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
A number without a suitability record is a number from an unknown instrument
System suitability is the set of checks demonstrating that the instrument and method were performing adequately when your sample was injected. It is recorded as a matter of…
Chengdu export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Turkey health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Denmark pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
How a claim degrades between the bench and the listing
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
A spectrum is a photograph of an ion, not of a molecule
The two ionisation techniques in general use produce different charge distributions, different adducts and different failure modes. Certificates almost never say which was…
Janoshik result on a Zhuhai liraglutide lot lands 1.0 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
What a 30% rise in coupling-reagent prices does to a 10 mg vial
Follow the resin, not the catalogue.
India pharmacy body issues counselling standards for tirzepatide initiation
The evidence base is thin and the document says so, which is to its credit.
Calder Vale Peptides of Skipton enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Holding the dose before surgery: for whom, for how long
A drug that delays gastric emptying complicates the assumption behind every fasting instruction in perioperative medicine. The professional bodies have moved twice on this…
A tested vial is evidence about a vial
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
What happens when the drug is taken away: three randomised answers
What was withdrawn, from whom, after how long, and what was measured afterwards.
Singapore declines to reimburse tirzepatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.