Inspectors cite Halvard & Pike Apothecary of Portland, Maine over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Archive — September 2025
Page 3 of 5 of this archive, newest first.
What TRIUMPH-1 tells us about maintenance, and what it does not
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
What STEP 4 and SURMOUNT-4 actually established
Weight reduction in the long programmes flattens at roughly sixty to seventy-two weeks. The timing is consistent, predictable and almost never mentioned in advance.
What the new Switzerland guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The online reseller trading as Adamant Research Supply closes after 18 years
A proper account of an operation that existed, and of what closing it cost.
South Korea caps tirzepatide prescribing to 24 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What the outcome trials measured in the kidney
Estimated glomerular filtration rate is a calculation with muscle mass in the denominator of its assumptions. In this population that matters.
Who signed this, and what did they undertake by signing it
Accreditation is granted for a defined scope of methods. A laboratory can be properly accredited and the test on your certificate can sit outside it.
A supplier suspends shipping to Turkey after 13 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Norway declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
STEP 2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
An interlaboratory comparison nobody had run
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
The limits of mechanism: why receptor data will not tell you who responds
A catalogue of open questions, with an assessment of how likely each is to be resolved.
What Medutest would need in order to certify sterility, and why it does not
A compendial sterility test takes fourteen days of incubation and consumes the containers tested. That timescale is incompatible with the business model that made…
Inspectors cite Calder Vale Peptides of Skipton over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The 11-day notice: how a compounding wind-down works in Mexico
The document is four pages. Three of them are about dates.
TFC declines, for the 4th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a TFC cagrilintide lot at 95.9%, against 95.2% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
What column temperature does to selectivity
We set out the parameters a method disclosure would contain, all of which are known to whoever ran the sample and none of which is commercially sensitive.
The quiet end of the relabeller trading as Vantris Bio
A proper account of an operation that existed, and of what closing it cost.
The Netherlands pharmacy body issues counselling standards for tirzepatide initiation
The evidence base is thin and the document says so, which is to its credit.
What a 30% rise in coupling-reagent prices does to a 30 mg vial
Follow the resin, not the catalogue.
VendorInvestigate result on a Xianning liraglutide lot lands 2.5 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Three services, one lot, and a spread of two and a half points
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
In-use periods, and the ones nobody can give you
Sharps disposal is a legal obligation in most jurisdictions and a safety obligation everywhere. Household waste is not a route.
Janoshik result on a Hangzhou retatrutide lot lands 0.8 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
What changed at ERP in September, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
SWB declines, for the 18th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The Netherlands declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The interventions with trial support, and the much longer list without
The intervention with the clearest evidence is the one nobody frames as an intervention: adjusting the dose.
Same material, different gradients, different answers
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
A unit is not a dose, and it never was
Dead space in the needle hub is a real and calculable loss, and it matters more at small volumes than anybody expects.
STEP 1 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to Brazil after 7 consecutive customs detentions
The route did not close because of a rule about peptides.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
What a low result means when intake has halved
Micronutrient guidance for this drug class is borrowed almost entirely from post-bariatric surveillance, where the anatomy is different and the deficiency mechanisms are not…
SURPASS-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The relabeller trading as Vantris Bio closes after 3 years
A proper account of an operation that existed, and of what closing it cost.