Mean kinetic temperature is not the average temperature
The compendial definitions of cold, controlled cold and controlled room temperature permit specified excursions, and knowing the permitted band is the difference between an…
October 2025
Everything filed in October 2025, the month of Volume 2, Number 10. The issue itself — cover, editor’s letter and table of contents — is here.
GGPeps declines, for the 17th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 16-day notice: how a compounding wind-down works in Brazil
The document is four pages. Three of them are about dates.
Calder Vale Peptides of Skipton closes after 16 years
A proper account of an operation that existed, and of what closing it cost.
What a low result means when intake has halved
Reduced intake is a plausible mechanism for deficiency. Reduced absorption is not, and the two are conflated in most of the advice.
Blind duplicates: what happens when a laboratory does not know it is being watched
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
SURPASS-3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Switzerland pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Switzerland declines to reimburse tirzepatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
What the older diet-and-exercise trials found in the hip
The evidence base is one secondary analysis, several small studies and a large amount of extrapolation from bariatric surgery.
Size exclusion sees the thing reversed-phase dissolved
Where two methods disagree, the conservative convention is to report the lower figure. It is not universal, and whether a laboratory follows it belongs on the report.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
What the new Ireland guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
From the floor in Hangzhou: 22 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Janoshik result on a Chengdu orforglipron lot lands 3.8 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
What we asked twenty suppliers about stability data
Storage instructions in this market are close to uniform and almost never accompanied by the study that would justify them. Uniformity is a sign of convention, not of…
The out-of-range flag is a statistical convention with a printer attached
Two sources of noise sit under every number: how reproducible the assay is, and how much the analyte varies within the same person on the same day.
Ireland pharmacy body issues counselling standards for semaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Reproducibility, measured rather than assumed
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
How to check a certificate in ten minutes
What each missing test would cost to add, and which of them a buyer should actually want.
Why receptor selectivity is the least discussed number in incretin pharmacology
The class is described as though every molecule in it did the same thing. At the receptor, they demonstrably do not.
The 8-day notice: how a compounding wind-down works in Singapore
The document is four pages. Three of them are about dates.
The online reseller trading as Adamant Research Supply closes after 23 years
A proper account of an operation that existed, and of what closing it cost.
Sweden health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
QST declines, for the 17th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Two sessions a week, and the evidence behind the prescription
Mass and function are different endpoints and training affects them differently. Most coverage treats them as one.
The quiet end of the relabeller trading as Vantris Bio
A proper account of an operation that existed, and of what closing it cost.
New Zealand pharmacy body issues counselling standards for semaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Medutest result on a Zhuhai orforglipron lot lands 3.8 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
TRIUMPH-1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Percentage of loss, absolute kilograms, and the sleight of hand between them
A substudy powered to describe a mean is not a substudy powered to detect a clinically meaningful individual change.
Randomised withdrawal is the cleanest design in this field and the least discussed
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
What the new Australia guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What changed at SGN in October, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Medutest result on a Qingdao dulaglutide lot lands 1.4 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The glucagon receptor arm, and why it is the hardest to reason about
A dual agonist is one molecule with two receptor activities. A co-formulation is two molecules in one pen. The coverage treats them as synonyms.
What a batch number is supposed to mean
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.