Oxidation, and the peroxide that came in with the surfactant
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
The Supply Chain Dispatch
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
One of the suppliers the Journal tracks has suspended shipping to Australia following a run of consignments detained at the border. No statement has been published; the suspension is visible only in the checkout process, which no longer accepts addresses in that market. We have written to ask whether it is permanent and whether affected customers are being refunded.
Transit times on the lane moved from a median of nine days to a median of 27. Phase-change cold packs of the type commonly used in this trade are typically specified for 72 to 120 hours depending on configuration and ambient profile, which puts a substantial fraction of these shipments outside specification for the majority of the journey.
Transit times on the lane moved from a median of nine days to a median of 27. Phase-change cold packs of the type commonly used in this trade are typically specified for 72 to 120 hours depending on configuration and ambient profile, which puts a substantial fraction of these shipments outside specification for the majority of the journey.
Three of the twenty companies in the Journal’s dossier programme ship without any temperature indicator. On our own purchasing record, an unindicated parcel is not a parcel that stayed cold; it is a parcel about which nothing is known. Suppliers that require indicator evidence for a replacement claim while shipping no indicator have constructed an unfalsifiable position.
Peter Malinowski, former state board of pharmacy inspector, said the classification change would resolve itself. "These things always do, once the brokers learn the new code. The cost lands on whoever shipped in the first fortnight."
We have asked three suppliers whether they will begin shipping indicators as standard. Two have replied; the answers are in their dossiers.
Related coverage
Four millimetres is enough, and the data says so
A 4 mm needle at ninety degrees without a skin pinch is adequate for essentially all adults. The persistence of 12.7 mm needles in this market is habit, not reasoning.
Everything on the page, in the order a chemist would read it
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
Deamidation is the commonest degradation route and the hardest to see
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.
South Africa health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.