In-use periods, and the ones nobody can give you
The air shot before a pen injection removes air from the cartridge and confirms flow. Skipping it can mean a materially reduced dose, and it is skipped constantly.
Recent work
73 piecesThe one randomised trial that combined an incretin with supervised exercise
Mass and function are different endpoints and training affects them differently. Most coverage treats them as one.
The skeleton responds to load, and load is falling
The evidence base is one secondary analysis, several small studies and a large amount of extrapolation from bariatric surgery.
What the placebo arms of the withdrawal trials actually tell us
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
The lead-in, the randomisation, and the year that followed
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
Benzyl alcohol is a preservative, not a sterilising agent
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
The skeleton responds to load, and load is falling
Weight loss reduces bone mineral density at load-bearing sites. Whether that translates into fractures in this population is unmeasured.
Aseptic technique for people who were never taught it
For licensed products the in-use period is established by stability data. For a peptide reconstituted at home there is no such data, and the honest answer is that nobody…
Measuring more frequently generates more flags and not more information
The argument for a baseline panel is that it makes every subsequent result interpretable. The argument against frequent monitoring is that noise accumulates faster than…
Why SSA can be entirely straightforward and still tell you nothing about bioburden
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
A guide to the results that will resolve themselves
A substantial proportion of the abnormal results generated during rapid weight loss are consequences of the weight loss rather than findings about the person.
What the older diet-and-exercise trials found in the hip
The evidence base is one secondary analysis, several small studies and a large amount of extrapolation from bariatric surgery.
What the upper limit of normal for ALT should be, and why it is not
What the renal and hepatic outcome programmes actually measured, and over what duration.
Same mass, different molecule: why identity by mass is not identity
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
What happens when the drug is taken away: three randomised answers
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
What happens when the drug is taken away: three randomised answers
What was withdrawn, from whom, after how long, and what was measured afterwards.
What changed after we published the first version of this
None of what this piece asks for is commercially sensitive, and all of it is already known to whoever released the batch.
A reference interval is not a target, and a result outside one is not a diagnosis
A twelve-analyte panel in a perfectly healthy person has roughly even odds of producing at least one flagged result.
Why the theoretical mass on the certificate might be the wrong theoretical mass
A worked example: one peptide, five charge states, five mass-to-charge ratios, one molecular weight.
Mean kinetic temperature is not the average temperature
The compendial definitions of cold, controlled cold and controlled room temperature permit specified excursions, and knowing the permitted band is the difference between an…