VendorInvestigate result on a Tianjin tirzepatide lot lands 0.7 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
Page 5 of 10 of this archive, newest first.
The report states the gradient, the wavelength and the integration threshold, which is more than most.
A reminder that a purity figure is the output of a method, and that methods differ.
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
What the Journal asks when a document arrives unsigned, and what the answers have been.
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The supplier has not disputed the finding. It has not explained the gap either.
A compendial sterility test takes fourteen days of incubation and consumes the containers tested. That timescale is incompatible with the business model that made…
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The supplier has not disputed the finding. It has not explained the gap either.
The report states the gradient, the wavelength and the integration threshold, which is more than most.
A shallow gradient resolves impurities that a steep one runs into the parent peak. Both methods are legitimate; only one of them can see the small stuff.
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Endotoxin is the more tractable of the two questions, and a kinetic chromogenic determination is neither slow nor exotic. It is simply not on the menu.
The supplier has not disputed the finding. It has not explained the gap either.
A reminder that a purity figure is the output of a method, and that methods differ.
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
The result is unremarkable. What the report omits is not.
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
The supplier has not disputed the finding. It has not explained the gap either.