The advice is mostly reasonable. The certainty is not earned.
Grading six widely repeated claims against the studies actually behind them.
Patient Notes in 2024
Page 8 of 10 of this archive, newest first.
Spain pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Side effects, cost, supply, target: four reasons with four trajectories
Why the reason for stopping changes what happens afterwards.
What the new the United Kingdom guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Vitamin D, adiposity, and a volume-of-distribution problem
Reduced intake is a plausible mechanism for deficiency. Reduced absorption is not, and the two are conflated in most of the advice.
What the new South Korea guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What the new Germany guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What the trials adjudicated, and how
The features that should prompt urgent assessment, stated once and plainly.
Germany pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
What STEP 4 and SURMOUNT-4 actually established
The dose-response curve in this class flattens near its top. That has direct consequences for whether the final rung is worth climbing.
What the new Saudi Arabia guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
South Africa pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The advice is mostly reasonable. The certainty is not earned.
A tour of the source literatures, with an assessment of how far each legitimately reaches.
Thiamine and the vomiting patient
What the trials measured, which in the case of micronutrients is very little.
What the new Italy guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
India pharmacy body issues counselling standards for tirzepatide initiation
The evidence base is thin and the document says so, which is to its credit.
Percentage of loss, absolute kilograms, and the sleight of hand between them
A substudy powered to describe a mean is not a substudy powered to detect a clinically meaningful individual change.
Turkey pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
What the new Germany guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The supply gap as a clinical event
Cost is the modal reason for discontinuation in every dataset we have seen, and it is absent from the clinical literature.