How much water: the question with no single right answer
A more concentrated reconstitution means smaller injection volumes, which means larger proportional errors from graduation, dead space and technique.
September 2024
Everything filed in September 2024, the month of Volume 1, Number 9. The issue itself — cover, editor’s letter and table of contents — is here.
A supplier suspends shipping to Poland after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
What a 20% rise in coupling-reagent prices does to a 5 mg vial
Follow the resin, not the catalogue.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
The named comparison we promised two years ago
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
What Sweden customs does to a parcel it has decided to examine
A gel pack has a finite thermal budget, and once it is spent the payload equilibrates with whatever is outside the box. The only question is how long that takes.
The 27-day notice: how a compounding wind-down works in South Korea
The document is four pages. Three of them are about dates.
Guangzhou export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Independent analysis puts a WXT tirzepatide lot at 96.4%, against 93.6% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Custody, condition and the temperature nobody logged
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
The dose that got you here and the dose that keeps you here
What the labels permit, what clinicians do, and the size of the gap between them.
VendorInvestigate result on a Wuxi semaglutide lot lands 2.1 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
What changed at BCH in September, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Janoshik result on a Wuxi survodutide lot lands 2.9 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
From the floor in Suzhou: 6 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the placebo arms of the withdrawal trials actually tell us
What was withdrawn, from whom, after how long, and what was measured afterwards.
Why a result on one vial says less than the trade needs it to
Every third-party report in this market describes a sample somebody chose to send. That choice is outside the laboratory’s control and outside its records.
Independent analysis puts a BCH mazdutide lot at 98.6%, against 96.0% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Nigeria pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
What changed at HJ in September, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Why the bone question is harder than the muscle question
What the Journal would want measured before treating this as settled in either direction.
Holding the dose before surgery: for whom, for how long
The evidence is real, modest, and mostly retrospective. The guidance is correspondingly cautious and has been revised toward individualisation.
Reproducibility, measured rather than assumed
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
From the floor in Shenzhen: 5 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
GGPeps declines, for the 15th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Accumulation, trough, and the exposure curve nobody draws for patients
An accumulation model, drawn from published parameters, with its assumptions stated.
The 17-day notice: how a compounding wind-down works in the United Kingdom
The document is four pages. Three of them are about dates.
Halvard & Pike Apothecary of Portland, Maine closes after 4 years
A proper account of an operation that existed, and of what closing it cost.
What a 33% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
VendorInvestigate result on a Guangzhou liraglutide lot lands 3.6 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Why people actually stop, in the order they actually stop
Real-world persistence figures, with their definitions stated, because the definitions are doing most of the work.
What “LC-MS: conforms” tells a reader, which is almost nothing
What the Journal asks for when it writes to a supplier about an identity claim, and how often it gets it.
A shortage listing ends. 16 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Nigeria health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
TRIUMPH-1 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
How far back does this document actually reach?
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.