The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Archive — December 2024
Page 4 of 5 of this archive, newest first.
A supplier suspends shipping to Nigeria after 23 consecutive customs detentions
The route did not close because of a rule about peptides.
LEADER misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The supply gap as a clinical event
The trials studied planned withdrawal. Almost nobody stops that way.
A tested vial is evidence about a vial
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
A supplier suspends shipping to Brazil after 18 consecutive customs detentions
The route did not close because of a rule about peptides.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Ireland caps exenatide prescribing to 19 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-OSA extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The badge is about a sample. The listing is about a product.
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
In-use periods, and the ones nobody can give you
Sharps disposal is a legal obligation in most jurisdictions and a safety obligation everywhere. Household waste is not a route.
The 11-day notice: how a compounding wind-down works in Norway
The document is four pages. Three of them are about dates.
Inspectors cite Halvard & Pike Apothecary of Portland, Maine over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The United Arab Emirates health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
CPC declines, for the 15th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
One vial, four weeks, and the data that does not exist
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
We asked four laboratories for a sterility test. Here is what came back.
The absence of microbiological capability in this market is a commercial fact with a straightforward explanation, and it is worth understanding before blaming anybody for it.
The hormonal adaptations persist for years. That is the mechanism.
The physiology of regain was described a decade before these drugs, and it explains the trajectory without invoking anything specific to them.
VendorInvestigate result on a Chengdu cagrilintide lot lands 3.1 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at QSC in December, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Reflux, early satiety, and the volume the stomach will accept
The clinical effect profile is almost fully predictable from where the receptor is expressed, which is unusual and useful.
Spain health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
South Africa pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
What changed at ERP in December, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What changed after we published the first version of this
A reader holding a certificate can work out what it does not cover in about ninety seconds, and that is a useful ninety seconds.
Choosing a needle for a subcutaneous peptide
Gauge affects pain and flow rate rather than depth. A finer needle is more comfortable and slower, and with a viscous solution the difference is noticeable.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
From the floor in Guangzhou: 10 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the new Brazil guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Changsha export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The lowest effective dose is a real concept with almost no data behind it
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
Ireland caps tirzepatide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at CPC in December, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What changed at QYB in December, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
How far back does this document actually reach?
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Dose-limiting: a definition worth being strict about
Roughly four to seven per cent of trial participants discontinued for adverse events, mostly gastrointestinal, mostly during escalation. That is the empirical size of the…
Spain health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.