Nought point nine eight of a dalton: the modification that hides in plain sight
What would be needed to catch each of these, and what it would cost.
January 2025
Everything filed in January 2025, the month of Volume 2, Number 1. The issue itself — cover, editor’s letter and table of contents — is here.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Singapore caps liraglutide prescribing to 14 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What a 13% rise in coupling-reagent prices does to a 5 mg vial
Follow the resin, not the catalogue.
Who signed this, and what did they undertake by signing it
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.
Seasonal use, holiday use, and the honest state of the evidence
The schedules in circulation, described accurately, with their evidentiary status attached.
From the floor in Xi'an: 23 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Turkey declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Wuhan export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
A supplier suspends shipping to the Netherlands after 17 consecutive customs detentions
The route did not close because of a rule about peptides.
What the GLP-1 receptor actually does when exenatide binds it
The receptor is expressed in more tissues than the popular account allows, and that is the whole story.
The mechanism behind the mechanism
The receptor populations that produce satiety and the ones that produce nausea overlap substantially. That is why the ceiling of this drug class is where it is, and it is…
Inspectors cite the consolidator trading as Meridian Freight Partners over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at CPC in January, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Bacteriostatic water, sterile water, and the 0.9 per cent that makes the difference
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
A number without a suitability record is a number from an unknown instrument
System suitability is the set of checks demonstrating that the instrument and method were performing adequately when your sample was injected. It is recorded as a matter of…
Independent analysis puts a WWB survodutide lot at 99.0%, against 97.4% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Zhuhai export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
The 10-day notice: how a compounding wind-down works in Portugal
The document is four pages. Three of them are about dates.
What the outcome trials measured in the kidney
Asymptomatic pancreatic enzyme elevation is common on treatment and is not pancreatitis. The distinction is clinical, not biochemical.
When to stop escalating and when to stop entirely
An effect is dose-limiting when it prevents adequate intake, prevents normal activity, or produces a risk of its own. Discomfort alone is not the test.
What SURPASS-4 tells us about maintenance, and what it does not
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
Janoshik result on a Suzhou semaglutide lot lands 0.7 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Spain pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Reproducibility, measured rather than assumed
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
SURMOUNT-3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
From the floor in Xianning: 4 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Why a result on one vial says less than the trade needs it to
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
What STEP 5 tells us about maintenance, and what it does not
The commonest real-world strategy in this drug class is the least studied one.
Nigeria declines to reimburse tirzepatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The consolidator trading as Meridian Freight Partners enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A supplier suspends shipping to Ireland after 21 consecutive customs detentions
The route did not close because of a rule about peptides.
How a claim degrades between the bench and the listing
The Journal does not treat a badge as evidence and states so wherever it reports one.
Holding a dose is a decision, not a failure
Nausea and gastric delay attenuate over weeks at an unchanged dose. That single physiological fact is the entire justification for holding.