TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
Page 3 of 5 of this archive, newest first.
Purity, content, identity, sterility and endotoxin are five separate determinations. A single sheet of paper carrying one of them is not evidence about the other four.
A proper account of an operation that existed, and of what closing it cost.
Reported from the analysis, not from a warning notice.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The route did not close because of a rule about peptides.
We work through the arithmetic in full, because it is short, and because the errors it prevents are order-of-magnitude errors.
Efficacy was never the question in this appraisal. Duration of treatment was.
Follow the resin, not the catalogue.
The document is four pages. Three of them are about dates.
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Reported from the analysis, not from a warning notice.
The document is four pages. Three of them are about dates.
The observation that closes a facility is rarely the dramatic one.
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
A single drug producing both constipation and diarrhoea looks contradictory until the motility data is read properly.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The supplier confirmed the determination and supplied the method behind its own figure inside a week.
The observation that closes a facility is rarely the dramatic one.
The evidence base is thin and the document says so, which is to its credit.
Weight loss reduces bone mineral density at load-bearing sites. Whether that translates into fractures in this population is unmeasured.
The Journal does not treat a badge as evidence and states so wherever it reports one.
Reported from the analysis, not from a warning notice.
A proper account of an operation that existed, and of what closing it cost.
The route did not close because of a rule about peptides.
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
Receptor pharmacology is strong on average effects and almost silent on individual variation. That gap is where most reader questions live.
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
A proper account of an operation that existed, and of what closing it cost.
Reported from the analysis, not from a warning notice.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A small number of serious gastrointestinal events occur in people taking these drugs. Distinguishing them from the expected effect profile is the most consequential…
Reported from the sessions, and from the two hours afterwards.
Reported from the analysis, not from a warning notice.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The document is four pages. Three of them are about dates.
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
Matching a retention time against a standard is evidence of consistency, not proof of identity. Two different species can elute at the same time on one method.