Holding a dose is a decision, not a failure
Every major phase 3 protocol in this class allowed escalation to be delayed for tolerability. Almost no product label explains the mechanics of doing so.
May 2025
Everything filed in May 2025, the month of Volume 2, Number 5. The issue itself — cover, editor’s letter and table of contents — is here.
From the floor in Shanghai: 7 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Mexico declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
FGP declines, for the 16th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The shortage years, and what they taught about interruption
Cost is the modal reason for discontinuation in every dataset we have seen, and it is absent from the clinical literature.
Twenty-eight days is a number from somebody else’s product
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at KP in May, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A vial can be 99.4 per cent pure and not sterile in the same afternoon
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
Gallstones during rapid weight loss: drug, or weight loss?
The features that should prompt urgent assessment, stated once and plainly.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Independent analysis puts a JEEP retatrutide lot at 97.1%, against 94.3% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Hangzhou export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
A supplier suspends shipping to Norway after 8 consecutive customs detentions
The route did not close because of a rule about peptides.
A year after stopping: what the trials found at the far end
Fat mass, lean mass, and the composition of regained weight — the thinnest literature in this piece.
Endotoxin is not a microorganism, and killing the bacteria does not remove it
Three compendial method families are in routine use and a fourth, based on a recombinant enzyme rather than crab lysate, is now compendial in its own right.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What a 15% rise in coupling-reagent prices does to a 30 mg vial
Follow the resin, not the catalogue.
New Zealand pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
What the upper limit of normal for ALT should be, and why it is not
The reference interval for alanine aminotransferase in most laboratories is derived from a population that included people with undiagnosed fatty liver.
The mechanism behind the mechanism
The receptor populations that produce satiety and the ones that produce nausea overlap substantially. That is why the ceiling of this drug class is where it is, and it is…
Check the vial, not the box
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Independent analysis puts a TFC semaglutide lot at 97.6%, against 95.9% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Xi'an export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
What the new Mexico guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
From the floor in Xianning: 11 posters, one theme
Reported from the sessions, and from the two hours afterwards.
From milligrams in a vial to units in a barrel
A more concentrated reconstitution means smaller injection volumes, which means larger proportional errors from graduation, dead space and technique.
Shenzhen export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Sweden declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
A supplier suspends shipping to Sweden after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Custody, condition and the temperature nobody logged
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
One measurement, twenty companies, forty compounds
The Journal has read several hundred certificates from twenty companies. The number is almost always there; the method behind it almost never is.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Calder Vale Peptides of Skipton closes after 5 years
A proper account of an operation that existed, and of what closing it cost.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Six words a verification badge would need to mean anything
A badge asserts that something was tested. It does not assert what, when, on whose sample, by what method, or whether the lot on sale is the lot that was tested.
The intramuscular injection nobody intended
A 4 mm needle at ninety degrees without a skin pinch is adequate for essentially all adults. The persistence of 12.7 mm needles in this market is habit, not reasoning.