What happens in solution that does not happen in the cake
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
November 2025
Everything filed in November 2025, the month of Volume 2, Number 11. The issue itself — cover, editor’s letter and table of contents — is here.
The 26-day notice: how a compounding wind-down works in Italy
The document is four pages. Three of them are about dates.
Zhuhai export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Independent analysis puts a SGN cagrilintide lot at 98.0%, against 96.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Mapping a rotation that you will actually follow
The evidence base here is the insulin injection-technique literature, which is large and transfers well on tissue questions.
What a month without the drug does to tolerability
The convention — resume lower, re-escalate — is not caution. It follows directly from the elimination half-life.
A supplier suspends shipping to the Netherlands after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
What changed at FGP in November, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Canada caps liraglutide prescribing to 5 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Halvard & Pike Apothecary of Portland, Maine closes after 16 years
A proper account of an operation that existed, and of what closing it cost.
Same material, different gradients, different answers
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
How much of exenatide weight loss can any instrument actually attribute?
A body-composition report gives four decimal places and no confidence interval. That is the whole difficulty in one sentence.
Independent analysis puts a GL Biochem semaglutide lot at 97.8%, against 94.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Shenzhen export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
The United Arab Emirates health authority warns on falsified exenatide pens
Reported from the analysis, not from a warning notice.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Falling ferritin is not always falling iron
A substantial proportion of the abnormal results generated during rapid weight loss are consequences of the weight loss rather than findings about the person.
The badge is about a sample. The listing is about a product.
Every step between the laboratory report and the product page removes information, and the badge is the last step.
Canada caps semaglutide prescribing to 23 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Inspectors cite the online reseller trading as Adamant Research Supply over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The 12-day notice: how a compounding wind-down works in Saudi Arabia
The document is four pages. Three of them are about dates.
TRIUMPH-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why people actually stop, in the order they actually stop
Why the reason for stopping changes what happens afterwards.
What a low result means when intake has halved
Reduced intake is a plausible mechanism for deficiency. Reduced absorption is not, and the two are conflated in most of the advice.
The retest date and the expiry date are not the same document
What would make a difference is not a regulator. It is three lines on a certificate, all of which are already known to whoever wrote it.
The quiet end of the consolidator trading as Meridian Freight Partners
A proper account of an operation that existed, and of what closing it cost.
Poland pharmacy body issues counselling standards for semaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
What changed at SWB in November, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the four services actually offer, test by test
Endotoxin is the more tractable of the two questions, and a kinetic chromogenic determination is neither slow nor exotic. It is simply not on the menu.
A supplier suspends shipping to the United Arab Emirates after 4 consecutive customs detentions
The route did not close because of a rule about peptides.
The consolidator trading as Meridian Freight Partners enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
BCH declines, for the 22nd time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Singapore health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
The wavelength decides which impurities exist
Peptide bonds absorb strongly near 214 nm; aromatic side chains absorb near 280 nm. A method reading at 280 is blind to any fragment lacking an aromatic residue.
What the trials counted as intolerance
We set out the questions that distinguish a symptom to manage from a dose to change.
The 25-day notice: how a compounding wind-down works in India
The document is four pages. Three of them are about dates.
Calder Vale Peptides of Skipton closes after 8 years
A proper account of an operation that existed, and of what closing it cost.
Saudi Arabia caps tirzepatide prescribing to 13 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
FLOW extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why a 0.036-dalton difference is the hardest number in peptide identity
Calibration drift is real, unremarkable, and the reason serious laboratories run internal standards.