An error taxonomy for a market without a pharmacist
The recurring errors in this market are not exotic. They are a small set of arithmetic and reading failures, each capable of moving a dose by a factor of two or ten.
TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
Everything filed in January 2026, the month of Volume 3, Number 1. The issue itself — cover, editor’s letter and table of contents — is here.
The recurring errors in this market are not exotic. They are a small set of arithmetic and reading failures, each capable of moving a dose by a factor of two or ten.
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The observation that closes a facility is rarely the dramatic one.
The document is four pages. Three of them are about dates.
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
Lyophilisation does not stop degradation. It slows every pathway by removing the solvent that most of them require, and the residue of solvent that remains sets the rate.
A reminder that a purity figure is the output of a method, and that methods differ.
A proper account of an operation that existed, and of what closing it cost.
The route did not close because of a rule about peptides.
Follow the resin, not the catalogue.
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
Two sources of noise sit under every number: how reproducible the assay is, and how much the analyte varies within the same person on the same day.
The document is four pages. Three of them are about dates.
The observation that closes a facility is rarely the dramatic one.
The route did not close because of a rule about peptides.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Real-world persistence figures, with their definitions stated, because the definitions are doing most of the work.
A chromatogram is silent on everything that does not absorb: counter-ions, water, inorganic salts and non-chromophoric excipients all contribute mass to the vial and nothing…
Follow the resin, not the catalogue.
Efficacy was never the question in this appraisal. Duration of treatment was.
The observation that closes a facility is rarely the dramatic one.
What the trials measured, which in the case of micronutrients is very little.
Trial adverse-event tables count episodes reported to a study nurse. They are the best data we have and they systematically under-record the mundane.
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Reported from the analysis, not from a warning notice.
Reported from the sessions, and from the two hours afterwards.
The route did not close because of a rule about peptides.
Constipation is the most tractable of the effects and the most consistently under-managed.
Reported from the analysis, not from a warning notice.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Reported from the sessions, and from the two hours afterwards.
The route did not close because of a rule about peptides.
What the labels permit, what clinicians do, and the size of the gap between them.
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Follow the resin, not the catalogue.
The evidence base is thin and the document says so, which is to its credit.
Reported from the sessions, and from the two hours afterwards.
We asked all four services what they can determine, on what timescale, at what price, and under what accreditation. The answers are printed in full.
We set out the questions that distinguish a symptom to manage from a dose to change.