Janoshik result on a Wuhan orforglipron lot lands 4.2 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Analytics
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Mass spectrometry answers a different question, properly
The most useful single addition to any purity determination is a second separation under a different pH or on a different stationary phase, and the second-most useful is a…
Janoshik result on a Guangzhou retatrutide lot lands 2.2 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Where the solvent front ends is a decision, not a fact
Regulated pharmaceutical practice has explicit reporting, identification and qualification thresholds. This trade has none, which is why a purity figure carries no…
Twenty-eight days is a number from somebody else’s product
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
Leucine, isoleucine, and a difference no balance can measure
Stereochemical inversion changes the molecule, changes its biology, and changes its mass by exactly nothing.
Independent analysis puts a KP liraglutide lot at 95.5%, against 91.6% on the certificate
The result is unremarkable. What the report omits is not.
Independent analysis puts a QSC orforglipron lot at 97.3%, against 94.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Janoshik result on a Xianning tirzepatide lot lands 1.3 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The conservative convention: report the lower of two numbers
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
Janoshik result on a Xi'an tirzepatide lot lands 1.1 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Independent analysis puts a CPC tirzepatide lot at 96.6%, against 92.7% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
We submitted vials for endotoxin determination and report the results, the method and the laboratory, because a pyrogen figure without a method is as empty as a purity…
Medutest result on a Tianjin semaglutide lot lands 2.4 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Janoshik result on a Changsha survodutide lot lands 1.0 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
A named analyst is the cheapest quality signal in this trade
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.
What twenty companies say about storage, and what they have measured
A retest date says that material should be re-examined before use. An expiry date says it should not be used. The trade uses the second word for the first concept.
The sample is not the batch
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
Independent analysis puts a WWB semaglutide lot at 96.9%, against 93.3% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
A spectrum is a photograph of an ion, not of a molecule
A brief and unromantic tour of the interface between a liquid sample and a vacuum.