When a template becomes a misrepresentation
A PDF carries metadata about the software that produced it, and that metadata is frequently more informative than the content.
Explainers in 2025
Page 2 of 5 of this archive, newest first.
Severity grading, and the gap between a grade and an experience
Severity in these tables is graded by interference with activity, not by how unpleasant the experience was. Those are different measurements.
What a purity certificate is silent about
A purity figure is silent on peptide content, on water, on counter-ion, on sterility, on endotoxin and on stability. Each of those silences has a price attached.
The label says four weeks. The clinic says whatever holds.
The published ladder exists because a protocol needed a single number. Practice has never followed it exactly, and the regulatory file never assumed it would.
Retest date, expiry date, and the two conventions being confused
A document is only as good as the chain that connects it to the material, and most chains here are two or three links longer than the paperwork admits.
Gallstones during rapid weight loss: drug, or weight loss?
Pancreatitis is rare, was adjudicated in the outcome programmes, and did not show the imbalance early case reports suggested.
What the trial protocols permitted, and what the labels omitted
Reducing a dose is not going backwards. In a tolerability-limited class it is the mechanism by which the ceiling is found.
What column temperature does to selectivity
We set out the parameters a method disclosure would contain, all of which are known to whoever ran the sample and none of which is commercially sensitive.
Diminishing returns, quantified
Where the curve flattens, what flattens with it, and what does not.
The word “confirmed” is doing an enormous amount of work on this certificate
An intact mass measurement establishes elemental composition, at best. The number of distinct sequences consistent with a given composition is astronomically large.
Retention time is not identity
Matching a retention time against a standard is evidence of consistency, not proof of identity. Two different species can elute at the same time on one method.
Why your endoscopist wants to know about your injection
This is the single interaction with ordinary medical care that patients most need to disclose, and it is the one most often not asked about.
What the trials counted as intolerance
Trial discontinuation figures are a floor, not an estimate: trial populations are supported in ways ordinary patients are not.
Why Medutest can tell you the mass is right and not that the sequence is
The Journal’s standing position: a mass that matches is necessary evidence of identity and nowhere near sufficient.
The one place the insulin literature and this class agree completely
Repeated injection into the same small area produces lipohypertrophy — thickened, rubbery subcutaneous tissue with blunted and erratic absorption. It is common, it is…
What the GLP-1 receptor actually does when survodutide binds it
The receptor is expressed in more tissues than the popular account allows, and that is the whole story.
The eighteenth month, and the conversation that should have happened in the third
What the trials measured was continuation against withdrawal. What patients want to know is continuation at a lower dose, and that study has largely not been done.
What a batch number is supposed to mean
A document is only as good as the chain that connects it to the material, and most chains here are two or three links longer than the paperwork admits.
A supply gap is a pharmacological event
One omitted dose is a labelling question. Four omitted doses is a clinical one. The two are routinely conflated.
The software decides what counts as a peak
Baseline placement under a tailing peak is a judgement call with a direct effect on the area. It is one of the few places where two competent analysts genuinely disagree.