SURMOUNT-4 was built to answer the stopping question, and it did
The regain trajectories, arm by arm, with the estimands named.
Shortage listings
Drug shortage declarations, the compounding they permitted, and their resolution.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
What the labels permit, what clinicians do, and the size of the gap between them.
A shortage listing ends. 7 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 9-day notice: how a compounding wind-down works in the United Arab Emirates
The document is four pages. Three of them are about dates.
A shortage listing ends. 10 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 16-day notice: how a compounding wind-down works in the United Kingdom
The document is four pages. Three of them are about dates.
The dose that got you here and the dose that keeps you here
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The 26-day notice: how a compounding wind-down works in the United Kingdom
The document is four pages. Three of them are about dates.
A shortage listing ends. 16 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 29-day notice: how a compounding wind-down works in Mexico
The document is four pages. Three of them are about dates.
Side effects, cost, supply, target: four reasons with four trajectories
Real-world persistence figures, with their definitions stated, because the definitions are doing most of the work.
A shortage listing ends. 24 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Side effects, cost, supply, target: four reasons with four trajectories
The trials studied planned withdrawal. Almost nobody stops that way.
A shortage listing ends. 5 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Why people actually stop, in the order they actually stop
A supply interruption is a discontinuation with no notice, no taper and no plan. That is a distinct clinical situation.
The 23-day notice: how a compounding wind-down works in Singapore
The document is four pages. Three of them are about dates.
A shortage listing ends. 9 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What the placebo arms of the withdrawal trials actually tell us
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
What STEP 2 tells us about maintenance, and what it does not
What the labels permit, what clinicians do, and the size of the gap between them.
A shortage listing ends. 13 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.