The impurity hiding underneath the parent peak
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
January 2024
Everything filed in January 2024, the month of Volume 1, Number 1. The issue itself — cover, editor’s letter and table of contents — is here.
A supplier suspends shipping to Singapore after 12 consecutive customs detentions
The route did not close because of a rule about peptides.
SURPASS-3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The United Arab Emirates caps tirzepatide prescribing to 11 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Six words a verification badge would need to mean anything
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Units, millilitres, milligrams: three scales on one small object
A unit is a volume. A dose is a mass. The bridge between them is concentration, and concentration is a number somebody has to calculate.
What the new France guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
SURMOUNT-4 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Saudi Arabia declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
The badge is about a sample. The listing is about a product.
The Journal does not treat a badge as evidence and states so wherever it reports one.
A guide to the results that will resolve themselves
The panel drawn during a week of vomiting is measuring the vomiting.
Saudi Arabia caps exenatide prescribing to 11 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at SWB in January, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Denmark caps exenatide prescribing to 22 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Halvard & Pike Apothecary of Portland, Maine closes after 4 years
A proper account of an operation that existed, and of what closing it cost.
What happens when the drug is taken away: three randomised answers
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
Mass spectrometry answers a different question, properly
Where two methods disagree, the conservative convention is to report the lower figure. It is not universal, and whether a laboratory follows it belongs on the report.
The quiet end of the relabeller trading as Vantris Bio
A proper account of an operation that existed, and of what closing it cost.
A supplier suspends shipping to France after 3 consecutive customs detentions
The route did not close because of a rule about peptides.
What changed at QST in January, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Why the bone question is harder than the muscle question
Weight loss reduces bone mineral density at load-bearing sites. Whether that translates into fractures in this population is unmeasured.
Why receptor selectivity is the least discussed number in incretin pharmacology
Selectivity, potency and efficacy are three different measurements. The trade routinely reports none of them.
How a claim degrades between the bench and the listing
The Journal does not treat a badge as evidence and states so wherever it reports one.
Calder Vale Peptides of Skipton closes after 5 years
A proper account of an operation that existed, and of what closing it cost.
What the new Turkey guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Wuhan export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Denmark health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
Resolving power and mass accuracy are two different specifications
Every instrument specification quoted in an advertisement is a best case obtained on a calibration mixture, not on a submitted vial.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The consolidator trading as Meridian Freight Partners closes after 9 years
A proper account of an operation that existed, and of what closing it cost.
What changed at WWB in January, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Why people actually stop, in the order they actually stop
Cost is the modal reason for discontinuation in every dataset we have seen, and it is absent from the clinical literature.
Site selection when the tissue has already changed
A rotation scheme that is too complicated will not be followed. We describe the simple ones that are.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Independent analysis puts a BCH tirzepatide lot at 98.3%, against 94.9% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
SURMOUNT-2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The certificate says 2024. The vial in your hand does not say anything.
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
Dose-limiting: a definition worth being strict about
Roughly four to seven per cent of trial participants discontinued for adverse events, mostly gastrointestinal, mostly during escalation. That is the empirical size of the…