The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
Archive — January 2024
Page 4 of 5 of this archive, newest first.
A shortage listing ends. 8 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Suzhou export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
What the paperwork is for, and who it was designed to protect
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
What STEP 4 and SURMOUNT-4 actually established
Two withdrawal-design trials tell us what happens when treatment stops. Neither tells us what the lowest effective maintenance dose is.
A supplier suspends shipping to Canada after 24 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Canada caps exenatide prescribing to 11 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What a 39% rise in coupling-reagent prices does to a 15 mg vial
Follow the resin, not the catalogue.
The glycated haemoglobin assay, and the eight conditions that break it
The assay is not the problem. The interpretation of a lagging integral as a current measurement is the problem.
Why PeptideMeter may run electrospray where another laboratory runs MALDI
A brief and unromantic tour of the interface between a liquid sample and a vacuum.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
From the floor in Xianning: 4 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Independent analysis puts a MKM cagrilintide lot at 98.9%, against 94.9% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Qingdao export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Stepping down against stopping: two decisions treated as one
These agents produce no dependence and no withdrawal syndrome. What a taper would be for is therefore a real question rather than an obvious one.
Forty-four per cent: reading the nausea figure properly
Trial adverse-event tables count episodes reported to a study nurse. They are the best data we have and they systematically under-record the mundane.
From vial to bench: what is recorded and what is assumed
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at CPC in January, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Attribution is the hard part
We give background rates alongside trial rates, because an event occurring during treatment is not thereby caused by it.
Spain health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
A supplier suspends shipping to Australia after 5 consecutive customs detentions
The route did not close because of a rule about peptides.
SURMOUNT-OSA extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The submitted sample: the weakest link in the whole system
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
Why a 0.036-dalton difference is the hardest number in peptide identity
Parts per million sound impressive until they are converted into daltons at the molecular weight of the thing being measured.
Medutest result on a Xianning orforglipron lot lands 2.7 points above the supplier’s stated figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The online reseller trading as Adamant Research Supply closes after 11 years
A proper account of an operation that existed, and of what closing it cost.
The 28-day notice: how a compounding wind-down works in Sweden
The document is four pages. Three of them are about dates.
Shenzhen export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Everything on the page, in the order a chemist would read it
Nothing on this page is difficult. It is simply unfamiliar, and unfamiliarity is what makes a weak certificate look like a strong one.
What a 1 mL syringe does that a 0.3 mL syringe does not
A unit is a volume. A dose is a mass. The bridge between them is concentration, and concentration is a number somebody has to calculate.
Saudi Arabia caps liraglutide prescribing to 18 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at Homopeptide in January, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What changed at GL Biochem in January, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A design note on withdrawal trials, and why the run-in matters
A withdrawal trial answers a narrower question than it appears to. This piece states which question.
What twenty companies say about storage, and what they have measured
What would make a difference is not a regulator. It is three lines on a certificate, all of which are already known to whoever wrote it.
Independent analysis puts a BCH semaglutide lot at 95.2%, against 91.2% on the certificate
The supplier confirmed the determination and supplied the method behind its own figure inside a week.