Matrix, laser, needle: the plumbing that determines what you see
A brief and unromantic tour of the interface between a liquid sample and a vacuum.
The archive — 2024
Page 51 of 68 of this archive, newest first.
Why your endoscopist wants to know about your injection
This is the single interaction with ordinary medical care that patients most need to disclose, and it is the one most often not asked about.
What the sequence tells you about how a peptide will fail
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
Spain pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
VendorInvestigate result on a Changsha dulaglutide lot lands 3.5 points above the supplier’s stated figure
A reminder that a purity figure is the output of a method, and that methods differ.
Equal area is not equal mass: the response factor problem
Peptide bonds absorb strongly near 214 nm; aromatic side chains absorb near 280 nm. A method reading at 280 is blind to any fragment lacking an aromatic residue.
Tolerability is the ceiling, and the ceiling is personal
The ceiling varies severalfold between people, and nothing measurable at baseline predicts where it sits.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Halvard & Pike Apothecary of Portland, Maine closes after 19 years
A proper account of an operation that existed, and of what closing it cost.
Norway declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
BCH names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the upper limit of normal for ALT should be, and why it is not
Estimated glomerular filtration rate is a calculation with muscle mass in the denominator of its assumptions. In this population that matters.
A tested vial is evidence about a vial
Every third-party report in this market describes a sample somebody chose to send. That choice is outside the laboratory’s control and outside its records.
Inspectors cite Calder Vale Peptides of Skipton over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The 10-day notice: how a compounding wind-down works in Mexico
The document is four pages. Three of them are about dates.
Singapore caps tirzepatide prescribing to 11 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-OSA extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Same material, different gradients, different answers
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
Side effects, cost, supply, target: four reasons with four trajectories
Why the reason for stopping changes what happens afterwards.
The quiet end of the online reseller trading as Adamant Research Supply
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 24 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
SURPASS-2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Independent analysis puts a SWB dulaglutide lot at 96.2%, against 95.6% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Asparagine, glycine, and the two residues that decide a shelf life
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Grams per kilogram of what? The denominator problem in protein guidance
The practical difficulty is not knowing the target. It is meeting it on an appetite that has been pharmacologically reduced by half.
From the floor in Xianning: 17 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the new the United Kingdom guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What a 29% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.