Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The archive — 2024
Page 54 of 68 of this archive, newest first.
Four ways a peptide comes apart
Deamidation, oxidation, aggregation and hydrolysis account for nearly all of what happens to a peptide over time. Each has a characteristic residue, a characteristic…
What STEP 4 and SURMOUNT-4 actually established
The dose-response curve in this class flattens near its top. That has direct consequences for whether the final rung is worth climbing.
Australia health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
Shanghai export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
What the new Saudi Arabia guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
From the floor in Changsha: 11 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What happens when the drug is taken away: three randomised answers
The regain trajectories, arm by arm, with the estimands named.
The dose that got you here and the dose that keeps you here
What the labels permit, what clinicians do, and the size of the gap between them.
What changed at HJ in March, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A supplier suspends shipping to Saudi Arabia after 19 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
What the GLP-1 receptor actually does when mazdutide binds it
Selectivity, potency and efficacy are three different measurements. The trade routinely reports none of them.
Oxidation, and the peroxide that came in with the surfactant
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
South Africa pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The 22-day notice: how a compounding wind-down works in Ireland
The document is four pages. Three of them are about dates.
The consolidator trading as Meridian Freight Partners closes after 9 years
A proper account of an operation that existed, and of what closing it cost.
Norway caps liraglutide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The advice is mostly reasonable. The certainty is not earned.
A tour of the source literatures, with an assessment of how far each legitimately reaches.
D-amino acids are invisible to mass spectrometry, and that is the whole problem
What would be needed to catch each of these, and what it would cost.
Reflux, early satiety, and the volume the stomach will accept
What scintigraphy and breath-test studies established about emptying rate, and what they did not.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What a 25% rise in coupling-reagent prices does to a 10 mg vial
Follow the resin, not the catalogue.
VendorInvestigate result on a Hong Kong mazdutide lot lands 2.6 points above the supplier’s stated figure
The result is unremarkable. What the report states alongside it is not.
The quiet end of the consolidator trading as Meridian Freight Partners
A proper account of an operation that existed, and of what closing it cost.
The badge is about a sample. The listing is about a product.
The Journal does not treat a badge as evidence and states so wherever it reports one.
MKM names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a BCH cagrilintide lot at 96.1%, against 95.2% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Inspectors cite Halvard & Pike Apothecary of Portland, Maine over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Aggregation: the impurity your chromatogram dissolved before it looked
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.