SURPASS-3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Archive — April 2025
Page 4 of 5 of this archive, newest first.
The limits of mechanism: why receptor data will not tell you who responds
Receptor pharmacology is strong on average effects and almost silent on individual variation. That gap is where most reader questions live.
Four ways a peptide comes apart
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
What TRIUMPH-1 tells us about maintenance, and what it does not
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
TRIUMPH-3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to the United Arab Emirates after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Wuhan export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Mapping a rotation that you will actually follow
Repeated injection into the same small area produces lipohypertrophy — thickened, rubbery subcutaneous tissue with blunted and erratic absorption. It is common, it is…
What a month without the drug does to tolerability
Concentrations fall by half a week, so a month away leaves a small fraction of steady state. Resuming at the previous dose presents the receptor with a step it has not seen…
STEP 5 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Halvard & Pike Apothecary of Portland, Maine closes after 14 years
A proper account of an operation that existed, and of what closing it cost.
Janoshik result on a Xi'an tirzepatide lot lands 1.1 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
The cake tells you something, and it is not purity
Dye ingress and microbial immersion are probabilistic. Vacuum decay, high-voltage leak detection and helium mass spectrometry are deterministic and far more sensitive.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Italy pharmacy body issues counselling standards for semaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Independent analysis puts a CPC tirzepatide lot at 96.6%, against 92.7% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
The arithmetic behind every identity confirmation, worked in full
A peptide has a monoisotopic mass and an average mass, they differ by several daltons at this molecular size, and a certificate that does not say which it quotes cannot be…
The steps get smaller as the ladder gets higher, and that is deliberate
What the published pharmacokinetics permit, what the labels state, and where the two diverge.
What STEP 8 tells us about maintenance, and what it does not
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
SURPASS-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Saudi Arabia health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
From the floor in Qingdao: 3 posters, one theme
Reported from the sessions, and from the two hours afterwards.
The advice is mostly reasonable. The certainty is not earned.
The gap between a defensible recommendation and a confident one is where most of the harm in this subject lives.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
We submitted vials for endotoxin determination and report the results, the method and the laboratory, because a pyrogen figure without a method is as empty as a purity…
What a 27% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
Singapore caps dulaglutide prescribing to 15 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 9 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The cake is a record of the cycle that made it
Lyophilisation does not stop degradation. It slows every pathway by removing the solvent that most of them require, and the residue of solvent that remains sets the rate.
The header, the table and the signature block
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
Ireland pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
The online reseller trading as Adamant Research Supply closes after 19 years
A proper account of an operation that existed, and of what closing it cost.
The 28-day notice: how a compounding wind-down works in Germany
The document is four pages. Three of them are about dates.
Three receptors, one peptide: the design problem behind triple agonism
Head-to-head data exists for some of these comparisons and not for others. This piece says which.
The mechanism behind the mechanism
A single drug producing both constipation and diarrhoea looks contradictory until the motility data is read properly.
What the new Singapore guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.