What the new Spain guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Archive — April 2025
Page 3 of 5 of this archive, newest first.
Twenty-eight days is a number from somebody else’s product
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
The lowest effective dose is a real concept with almost no data behind it
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
From the floor in Hong Kong: 13 posters, one theme
Reported from the sessions, and from the two hours afterwards.
What the new Singapore guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What a 39% rise in coupling-reagent prices does to a 5 mg vial
Follow the resin, not the catalogue.
Leucine, isoleucine, and a difference no balance can measure
Stereochemical inversion changes the molecule, changes its biology, and changes its mass by exactly nothing.
Gallstones during rapid weight loss: drug, or weight loss?
The features that should prompt urgent assessment, stated once and plainly.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A supplier suspends shipping to Italy after 8 consecutive customs detentions
The route did not close because of a rule about peptides.
Wuxi export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Independent analysis puts a KP liraglutide lot at 95.5%, against 91.6% on the certificate
The result is unremarkable. What the report omits is not.
Vitamin D, adiposity, and a volume-of-distribution problem
Reduced intake is a plausible mechanism for deficiency. Reduced absorption is not, and the two are conflated in most of the advice.
Endotoxin is not a microorganism, and killing the bacteria does not remove it
Bacterial endotoxin is a heat-stable lipopolysaccharide from the outer membrane of Gram-negative organisms. It survives sterilisation, passes a sterilising filter, and is…
What the pharmacokinetics permit and what they cannot tell you
A great deal of practice has grown up around intermittent schedules. The randomised evidence for any of them is, as far as the Journal can establish, nil.
A supplier suspends shipping to the United Arab Emirates after 5 consecutive customs detentions
The route did not close because of a rule about peptides.
The quiet end of Halvard & Pike Apothecary of Portland, Maine
A proper account of an operation that existed, and of what closing it cost.
Sweden caps liraglutide prescribing to 10 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at JEEP in April, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Three weeks off is a fresh start, whether or not you want one
Concentrations fall by half a week, so a month away leaves a small fraction of steady state. Resuming at the previous dose presents the receptor with a step it has not seen…
What the new India guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Inspectors cite Halvard & Pike Apothecary of Portland, Maine over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Independent analysis puts a QSC orforglipron lot at 97.3%, against 94.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
SURPASS-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Choosing a needle for a subcutaneous peptide
A 4 mm needle at ninety degrees without a skin pinch is adequate for essentially all adults. The persistence of 12.7 mm needles in this market is habit, not reasoning.
Vagal afferents, the area postrema, and the anatomy of nausea
A tour of the tissues where the receptor is expressed, and what happens in each.
SURMOUNT-OSA misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
France health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
Janoshik result on a Xianning tirzepatide lot lands 1.3 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
What changed at QST in April, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
How a claim degrades between the bench and the listing
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Vitamin D, adiposity, and a volume-of-distribution problem
Micronutrient guidance for this drug class is borrowed almost entirely from post-bariatric surveillance, where the anatomy is different and the deficiency mechanisms are not…
A tested vial is evidence about a vial
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
The online reseller trading as Adamant Research Supply closes after 23 years
A proper account of an operation that existed, and of what closing it cost.
The 22-day notice: how a compounding wind-down works in Ireland
The document is four pages. Three of them are about dates.
The conservative convention: report the lower of two numbers
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
Italy health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Brazil pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.