Adverse events by dose, adverse events by week
Almost every figure in circulation about tolerability comes from six publications. This is what they say.
April 2026
Everything filed in April 2026, the month of Volume 3, Number 4. The issue itself — cover, editor’s letter and table of contents — is here.
The quiet end of the consolidator trading as Meridian Freight Partners
A proper account of an operation that existed, and of what closing it cost.
PeptideMeter result on a Changsha orforglipron lot lands 1.7 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
What a 25% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
System suitability: the five checks that make a run interpretable
Accreditation to the international competence standard covers the scope a laboratory has been assessed for, which is not necessarily the test you commissioned.
Dose-limiting: a definition worth being strict about
An effect is dose-limiting when it prevents adequate intake, prevents normal activity, or produces a risk of its own. Discomfort alone is not the test.
From the floor in Wuxi: 5 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Independent analysis puts a MKM dulaglutide lot at 98.2%, against 96.7% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Hong Kong export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
France pharmacy body issues counselling standards for exenatide initiation
The evidence base is thin and the document says so, which is to its credit.
Micronutrient monitoring: which panel, how often, and on whose evidence
A monitoring schedule requires evidence about incidence. For this population, that evidence does not exist.
An interlaboratory comparison nobody had run
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
Inspectors cite the online reseller trading as Adamant Research Supply over sterility assurance
The observation that closes a facility is rarely the dramatic one.
VendorInvestigate result on a Zhuhai survodutide lot lands 4.2 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
What changed at TFC in April, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 10-day notice: how a compounding wind-down works in Ireland
The document is four pages. Three of them are about dates.
Same material, different gradients, different answers
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
The lead-in, the randomisation, and the year that followed
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Poland declines to reimburse tirzepatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
HJ declines, for the 15th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The 24-day notice: how a compounding wind-down works in the United Kingdom
The document is four pages. Three of them are about dates.
The named comparison we promised two years ago
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
Adsorption, and the dose that stayed on the glass
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
Why the bone question is harder than the muscle question
A plausible mechanism, a measurable change, and no outcome data. This is what an open question looks like.
Germany caps semaglutide prescribing to 14 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at Homopeptide in April, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A supplier suspends shipping to Norway after 13 consecutive customs detentions
The route did not close because of a rule about peptides.
Why a drug that acts on the pancreas changes what food tastes like
Receptor expression maps explain the effect profile better than any dose-response curve.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Argentina caps semaglutide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The 8-day notice: how a compounding wind-down works in the United Arab Emirates
The document is four pages. Three of them are about dates.
From the floor in Shenzhen: 23 posters, one theme
Reported from the sessions, and from the two hours afterwards.
One vial, four weeks, and the data that does not exist
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
Gastric emptying is a mechanism, not a side effect
The central effects are not a bonus. On the current evidence they are the principal mechanism of weight loss.
SUSTAIN-6 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Independent analysis puts a MKM cagrilintide lot at 97.3%, against 95.9% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
The quiet end of the relabeller trading as Vantris Bio
A proper account of an operation that existed, and of what closing it cost.
A supplier suspends shipping to Mexico after 5 consecutive customs detentions
The route did not close because of a rule about peptides.
Seasonal use, holiday use, and the honest state of the evidence
A great deal of practice has grown up around intermittent schedules. The randomised evidence for any of them is, as far as the Journal can establish, nil.