What the new Brazil guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The archive
Page 108 of 170 of this archive, newest first.
Changsha export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The lowest effective dose is a real concept with almost no data behind it
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
Ireland caps tirzepatide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at CPC in December, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What changed at QYB in December, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
How far back does this document actually reach?
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Dose-limiting: a definition worth being strict about
Roughly four to seven per cent of trial participants discontinued for adverse events, mostly gastrointestinal, mostly during escalation. That is the empirical size of the…
Spain health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
SURMOUNT-4 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to Switzerland after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Benzyl alcohol is a preservative, not a sterilising agent
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
Why TFC can be entirely straightforward and still tell you nothing about bioburden
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
EGFR, cystatin C, and the check on the check
Estimated glomerular filtration rate is a calculation with muscle mass in the denominator of its assumptions. In this population that matters.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
What the new New Zealand guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The relabeller trading as Vantris Bio closes after 13 years
A proper account of an operation that existed, and of what closing it cost.
The lead-in, the randomisation, and the year that followed
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
Inspectors cite Calder Vale Peptides of Skipton over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Germany health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
STEP 2 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
The limit for a parenteral product is calculable from the dose and the body weight in two lines. Almost nobody in this trade performs the calculation.
Why no trial in this class has reported a strength endpoint
The composition data comes from imaging substudies enrolling a few score participants at selected sites. It is the best evidence available and it is thin.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Janoshik result on a Xianning semaglutide lot lands 4.3 points above the supplier’s stated figure
The supplier confirmed the determination and supplied the method behind its own figure inside a week.
PIONEER 6 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
What the new India guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.