Singapore caps semaglutide prescribing to 10 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The Ledger in 2025
Page 5 of 10 of this archive, newest first.
Saudi Arabia declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
What happens when the drug is taken away: three randomised answers
The regain trajectories, arm by arm, with the estimands named.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
Turkey declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Germany caps semaglutide prescribing to 4 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What a split-sample exercise can establish, and what it cannot
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
Germany declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Portugal declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The named comparison we promised two years ago
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
South Korea caps liraglutide prescribing to 6 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Custody, condition and the temperature nobody logged
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
Norway declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
STEP 2 was built to answer the stopping question, and it did
A withdrawal trial answers a narrower question than it appears to. This piece states which question.
Ireland declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Ireland caps dulaglutide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What a laboratory knows about the material it receives
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
Denmark caps exenatide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Nigeria declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The dose that got you here and the dose that keeps you here
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.