Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Stability
Page 15 of 20 of this archive, newest first.
A named analyst is the cheapest quality signal in this trade
What the Journal asks when a document arrives unsigned, and what the answers have been.
A supplier suspends shipping to the United Kingdom after 20 consecutive customs detentions
The route did not close because of a rule about peptides.
Four ways a peptide comes apart
Reversed-phase chromatography runs in an organic, acidic mobile phase that dissociates most non-covalent aggregates on the way to the detector.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
One vial, four weeks, and the data that does not exist
An in-use period is established by a dedicated study on a specific formulation in a specific container at a specific concentration. Borrowing one from a marketed product is…
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Portugal after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
What the sequence tells you about how a peptide will fail
Reversed-phase chromatography runs in an organic, acidic mobile phase that dissociates most non-covalent aggregates on the way to the detector.
Four ways a peptide comes apart
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
Oxidation, and the peroxide that came in with the surfactant
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
Two decimal places on a single injection is a rhetorical choice
The arithmetic of significant figures, applied to a document that routinely reports four of them.
Gauge, pain and flow rate
Gauge affects pain and flow rate rather than depth. A finer needle is more comfortable and slower, and with a viscous solution the difference is noticeable.
Lipohypertrophy, and the absorption it ruins
A rotation scheme that is too complicated will not be followed. We describe the simple ones that are.
A supplier suspends shipping to Mexico after 3 consecutive customs detentions
The route did not close because of a rule about peptides.
Collapse temperature, and the hour of the cycle where shelf life is lost
Lyophilisation does not stop degradation. It slows every pathway by removing the solvent that most of them require, and the residue of solvent that remains sets the rate.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What a 1 mL syringe does that a 0.3 mL syringe does not
The graduation interval differs between barrel sizes, and a 1 mL barrel is frequently marked in two-unit steps. Reading one as though it were marked in single units halves…
Twenty-eight days is a number from somebody else’s product
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
Retest date, expiry date, and the two conventions being confused
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.