Maintenance dosing: what is licensed, what is practised, and what is evidenced
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
July 2025
Everything filed in July 2025, the month of Volume 2, Number 7. The issue itself — cover, editor’s letter and table of contents — is here.
STEP 1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A supplier suspends shipping to Argentina after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
Calder Vale Peptides of Skipton enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A named analyst is the cheapest quality signal in this trade
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.
The mechanism behind the mechanism
The clinical effect profile is almost fully predictable from where the receptor is expressed, which is unusual and useful.
LEADER misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The relabeller trading as Vantris Bio closes after 24 years
A proper account of an operation that existed, and of what closing it cost.
VendorInvestigate result on a Wuhan mazdutide lot lands 3.4 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
We asked four laboratories for a sterility test. Here is what came back.
A compendial sterility test takes fourteen days of incubation and consumes the containers tested. That timescale is incompatible with the business model that made…
Why "muscle-sparing" is a marketing term and not a measurement
Grading six widely repeated claims against the studies actually behind them.
TRIUMPH-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Canada pharmacy body issues counselling standards for dulaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The quiet end of the online reseller trading as Adamant Research Supply
A proper account of an operation that existed, and of what closing it cost.
Independent analysis puts a QSC liraglutide lot at 99.2%, against 97.6% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Escalating onto a rising curve
What the published pharmacokinetics permit, what the labels state, and where the two diverge.
The certificate says 2025. The vial in your hand does not say anything.
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Inspectors cite the relabeller trading as Vantris Bio over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Turkey declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
What the GIP receptor adds: reading orforglipron as two drugs in one sequence
The glucagon arm raises energy expenditure and also raises hepatic glucose output. Balancing those is the whole engineering problem.
What happens to a stopper after the fourth needle
Multiple-dose vials are designed for a defined number of punctures. Nobody counts, and the elastomer does not care whether anybody counts.
A supply gap is a pharmacological event
One omitted dose is a labelling question. Four omitted doses is a clinical one. The two are routinely conflated.
A shortage listing ends. 17 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Germany caps semaglutide prescribing to 4 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
TRIUMPH-1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
What a split-sample exercise can establish, and what it cannot
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
Calder Vale Peptides of Skipton closes after 6 years
A proper account of an operation that existed, and of what closing it cost.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Germany declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
ERP declines, for the 22nd time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What twenty companies say about storage, and what they have measured
Storage instructions in this market are close to uniform and almost never accompanied by the study that would justify them. Uniformity is a sign of convention, not of…
The supply gap as a clinical event
Why the reason for stopping changes what happens afterwards.
A supplier suspends shipping to the Netherlands after 19 consecutive customs detentions
The route did not close because of a rule about peptides.
LEADER misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Independent analysis puts a GL Biochem liraglutide lot at 96.0%, against 93.9% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
The software decides what counts as a peak
Baseline placement under a tailing peak is a judgement call with a direct effect on the area. It is one of the few places where two competent analysts genuinely disagree.
Thiamine and the vomiting patient
Reduced intake is a plausible mechanism for deficiency. Reduced absorption is not, and the two are conflated in most of the advice.